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ea0019p156 | Diabetes, Metabolism and Cardiovascular | SFEBES2009

Differences in hepatic fatty acid metabolism explain contrasting body weight and steatohepatitis in dietary models of non-alcoholic fatty liver disease in mice

Macfarlane D , Andrew R , Morton N , Nyirenda M , Iredale J , Walker B

Background: In mice, a methionine-choline deficient diet (MCDD) causes steatohepatitis and hepatic insulin resistance. In contrast, a simple choline-deficient diet (CDD) causes liver fat accumulation without steatohepatitis, insulin resistance or weight loss. We hypothesised that differences in liver and adipose fatty acid metabolism underlie the contrasting predisposition to steatohepatitis and hepatic insulin resistance.Methods: C57Bl6 mice (male, aged...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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